Association of Human Leukocyte Antigen Polymorphisms With Moderate-to-Severe Dry Eye With and Without Sjogren's Syndrome.

ABSTRACT:

Purpose

Sjögren's syndrome dry eye (SSDE) has been described in relation to human leukocyte antigen (HLA) polymorphisms. It is unknown whether non-Sjögren's syndrome dry eye (NSDE) is related to HLA. This study aimed to evaluate the genetic association of HLA polymorphism with dry eye disease (DED). This was a cross-sectional study.

Methods

Patients with moderate-to-severe DED with and without Sjögren's syndrome (SS) were included. Oral swab samples were collected and HLA genotyping was performed using single-molecule real-time sequencing. The normal healthy population was used as the control group for the susceptibility alleles identification. The signs and symptoms of DED were compared between patients with and without susceptibility alleles.

Results

Sixty-four (64)

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12302039 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature