Bis-urea anion receptors: influence of receptor structure and anion nature on binding affinity and stability.

ABSTRACT: Complexation behavior of bis-urea receptors bearing nitro substituent at different proximities from urea binding site was investigated using isothermal titration calorimetry (ITC) and ¹H NMR (Nuclear Magnetic Resonance) titration experiments. Their binding interactions with fluoride (F^-), acetate (OAc^-), and dihydrogen phosphate (H₂PO₄ ^-) anions were examined to evaluate affinities, stoichiometries, and thermodynamic parameters. The nature of the anion and the position of the nitro substituent significantly influenced receptor binding ability. Receptors with ortho-nitro groups underwent decomposition upon interaction with F^-, forming 2-benzimidazolinone cyclic urea as evidence from relatively large positive

SUBMITTER: Hassan E 

PROVIDER: S-EPMC12302126 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature