Rhythm control benefits left ventricular function compared with rate control in patients with atrial fibrillation: A computational study.

ABSTRACT:

Background

Atrial fibrillation (AF) alters heart rate, rhythm regularity, and atrial contraction, which may contribute to an increased risk of heart failure. Although rate and rhythm control target different aspects of these disturbances, their specific effects on left ventricular (LV) function remain unclear.

Objective

The purpose of this study was to predict the independent and combined contribution of heart rate, rhythm regularity, and atrial contraction to LV function in patients with AF.

Methods

We predicted LV ejection fraction (EF) and stroke volume (SV) in 10 whole-heart patient-specific models of patients with AF while varying heart rate, rhythm regularity, and effectiveness of atrial contraction.AF was modeled as a fast, irregular heart rate with no atrial c

SUBMITTER: Barrows RK 

PROVIDER: S-EPMC12302171 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature