Chronic kidney disease in adults with sickle cell trait: a systematic review and meta-analysis.

ABSTRACT:

Abstract

Sickle cell trait (SCT) may increase the risk of chronic kidney disease (CKD). We aimed to determine the pooled statistics of the association between SCT and CKD. Studies published up to May 2024 that were available on PubMed, Embase, Global Health Library, and Web of Science were screened. We included studies that reported odds ratios or hazard ratios (HRs) of CKD and/or end-stage renal disease (ESRD) and that compared adults with SCT to those without SCT. The risk of bias was evaluated using the Risk Of Bias In Nonrandomized Studies-of Exposures tool. The pooled SCT prevalence was calculated among patients with CKD/ESRD. A random-effects analysis was performed. Only studies with low or some concerns of bias were included, corresponding to 18 847 participants with SCT and

SUBMITTER: Castro-Sesquen YE 

PROVIDER: S-EPMC12302175 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature