2D and 3D anticancer activity of diiron bis-cyclopentadienyl complexes incorporating flurbiprofen and chlorambucil.

ABSTRACT: The new diiron complex [Fe₂Cp₂(CO){Ph₂P(4-C₆H₄CO₂H)}(μ-CO){μ-CNMe(Cy)}]CF₃SO₃, [2]CF₃SO₃ (Cp = η⁵-C₅H₅, Cy = C₆H₁₁), was synthesized with a 92% yield from a tricarbonyl precursor and 4-(diphenylphosphanyl)benzoic acid. The carboxylic acid group in [2]⁺ was exploited for bio-conjugation with flurbiprofen and chlorambucil through esterification procedures, affording complexes [3-4]CF₃SO₃ (36-55% yields). Comprehensive characterization of the products was achieved using IR, multinuclear NMR spectroscopy and mass spectrometry. The log P _ow values and the stability under physiologic

SUBMITTER: Biancalana L 

PROVIDER: S-EPMC12302230 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature