The polarity protein Par3 enhances renal cell carcinoma metastasis <i>via</i> YAP/TAZ activation.

ABSTRACT:

Objective

Partitioning defective protein 3 (Par3) has recently been found to have important roles in cancer progression. Interestingly, Par3's functions vary among cancers: both Par3 elevation (in the prostate or liver) and loss (in the breast or lung) have been implicated in cancer metastasis. Although Par3 overexpression has been correlated with diminished survival in renal cell carcinoma (RCC), data indicating the role of Par3 in RCC metastasis are lacking. Given reports of interactions between Par3 and oncoproteins such as Yes-associated protein (YAP)/WW domain-containing transcription regulator 1 (TAZ), we investigated whether Par3-mediated RCC metastasis might be due to activation of the Hippo pathway components YAP and TAZ.

Methods

Par3 levels were analyzed in RCC cel

SUBMITTER: Lee S 

PROVIDER: S-EPMC12302271 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature