Collagen Matrix Combined With Hydroxyapatite and Nasoseptal Flap for Skull Base Reconstruction.

ABSTRACT:

Background

Extended endoscopic endonasal transsphenoidal approaches (ExEETSA) commonly result in high-flow cerebrospinal fluid (CSF) leaks that demand robust reconstruction strategies. Although nasoseptal flap (NSF) is a standard reconstructive technique, high-flow grade 3 CSF leaks require additional rigid reconstruction. This study evaluated the long-term outcomes of collagen matrix-hydroxyapatite (HXA)-NSF for rigid skull base reconstruction without lumbar drain.

Methods

A retrospective cohort study was conducted on 100 patients undergoing ExEETSA involved intraoperative high-flow grade 3 CSF leak that were managed using a collagen matrix for dural repair followed by HXA and NSF reconstruction without lumbar drainage between January 2016 and December 2023. The primary out

SUBMITTER: Narayanan MS 

PROVIDER: S-EPMC12302278 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature