Modular, Tricomponent, and Concurrent One-Pot Synthesis of Libraries of γ-Keto Sulfones and γ-Keto Phosphine Oxides using Bronsted Acidic Eutectic Mixtures.

ABSTRACT: A modular, three-component, and sustainable one-pot/one-step protocol has been developed for the efficient and regioselective synthesis of libraries of γ-keto sulfones and γ-keto phosphine oxides through concurrent CC and CX bond formation (X = S or P). The acidic eutectic mixture ChCl/p-TSA·H₂O (1:2) (ChCl = choline chloride; p-TSA = p-toluenesulfonic acid) serves as both promoter and reaction medium. This transformation involves a cascade process comprising three consecutive steps: i) hydration of terminal alkynes to methyl ketones; ii) Claisen-Schmidt condensation with aldehydes, and iii) sulfa-Michael or phospha-Michael additions using sodium sulfinates or secondary phosphine oxides, respectively. The methodology provides high yields (up to 99%), excellent atom economy, an

SUBMITTER: Ramos-Martin M 

PROVIDER: S-EPMC12302313 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature