Serum metabolite biomarkers for the early diagnosis and monitoring of age-related macular degeneration.

ABSTRACT:

Introduction

Age-related macular degeneration (AMD) is a leading cause of irreversible blindness worldwide, with significant challenges for early diagnosis and treatment.

Objectives

To identify new biomarkers that are important for the early diagnosis and monitoring of the severity/progression of AMD.

Methods

We investigated the diagnostic and monitoring potential of blood metabolites in a cohort of 547 individuals (167 healthy controls, 240 individuals with other eye diseases as eye disease controls, and 140 individuals with AMD) from 2 centers over three phases: discovery phase 1, discovery phase 2, and an external validation phase. The samples were analyzed via a mass spectrometry-based, widely targeted metabolomic workflow. In discovery phases 1 and 2, we built a

SUBMITTER: Li S 

PROVIDER: S-EPMC12302346 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature