Hippocampal dipeptidyl peptidase 9 bidirectionally regulates memory associated with synaptic plasticity.

ABSTRACT:

Introduction

Subtypes of the dipeptidyl peptidase (DPP) family, such as DPP4, are reportedly associated with memory impairment. DPP9 is widely distributed in cells throughout the body, including the brain. However, whether DPP9 regulates memory has not yet been elucidated.

Objectives

This study aimed to elucidate the role of DPP9 in memory, as well as the underlying molecular mechanism.

Methods

We performed immunofluorescence on mouse brains to explore the distribution of DPP9 in different brain regions and used AAV vectors to construct knockdown and overexpression models. The effects of changing DPP9 expression on memory were demonstrated through behavioral experiments. Finally, we used electrophysiology, proteomics and affinity purification mass spectrometry (AP-MS)

SUBMITTER: Zhao YB 

PROVIDER: S-EPMC12302361 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature