<i>Zanthoxylum schinifolium</i> extracts enhance 3T3-L1 adipocyte differentiation via CHOP inhibition and PPARγ activation.

ABSTRACT: Zanthoxylum schinifolium (ZS), which is widely used as a seasoning and traditional medicine in East Asia, has demonstrated pharmacological potential. This study investigated the effects of the leaf and twig extracts of ZS (LZSE and TZSE, respectively), which are native to the Honam region of Korea, on adipocyte differentiation and assessed the ligand-binding energy score of their components to bind peroxisome proliferator-activated receptor gamma (PPARγ), a critical regulator of adipogenesis and metabolic health. LZSE and TZSE were prepared using 70% ethanol, and their molecular effects on adipocyte differentiation were evaluated in 3T3-L1 preadipocytes. Single compounds from the extracts were identified using UPLC-ESI-Q-TOF-MS, and their ligand-binding energy scores were calculated

SUBMITTER: Lee J 

PROVIDER: S-EPMC12302382 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature