Sophoridine inhibits proliferation and migration by targeting PIM1 in breast cancer.

ABSTRACT:

Context

Sophoridine, an alkaloid quinolizidine derived from Sophora flavescens Aiton (Fabaceae), has strong anti-tumor activity in a variety of malignancies. Nevertheless, the effects and underlying mechanism of sophoridine on breast cancer are not fully understood.

Objective

To identify the key targets and potential pharmacological mechanisms of sophoridine against breast cancer.

Materials and methods

MCF-10A, MCF-7 and MDA-MB-231 cells were treated with sophoridine for 24 or 48 h. MTT, colony formation assay, flow cytometry, wound healing, and Transwell assay were employed to illustrate the anti-tumor effects of sophoridine on breast cancer. Network pharmacology and molecular docking were used to determine the targets for sophoridine in breast cancer, and con

SUBMITTER: Chen L 

PROVIDER: S-EPMC12302398 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature