Cobalt-nickel metal-organic frameworks (CNMs) as drug delivery agents for triple-negative breast cancer.

ABSTRACT: Breast cancer is one of the most prevalent cancers worldwide, with triple-negative breast cancer (TNBC) representing a particularly aggressive subtype, making it difficult to treat, and is associated with a poor prognosis. However, chemotherapy is associated with challenges such as drug resistance, off-target toxicity, and limited efficacy, highlighting the need for more effective therapies. Nanocarriers, including liposomes, micelles, and dendrimers, offer improved drug delivery efficacy and reduced toxicity but face challenges in terms of stability and scalability. Metal-organic frameworks (MOFs) have emerged as promising drug delivery systems, particularly for combination therapies to overcome resistance in TNBC. In this study, cobalt-nickel metal-organic frameworks (CNMs) were synthesi

SUBMITTER: Basha SS 

PROVIDER: S-EPMC12302404 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature