Promotion of HIV clearance by sensitization of HIV reservoirs to cell death.

ABSTRACT:

Introduction

HIV integrates its proviral DNA into the host genome to establish persistent infection. To promote HIV clearance, we have designed an approach for selective elimination of host cells harboring replication-competent HIV (SECH), through inhibition of autophagy and anti-apoptotic molecules during viral reactivation. SECH approach can clear HIV-infected cells in approximately 50% humanized mice. However, the mechanisms for the resistance of reservoirs to depletion in mice with failure in HIV clearance are unclear.

Methods

We have performed single cell transcriptome analyses of HIV-infected T cells that escaped the treatments, in order to identify cellular pathways that could be targeted to facilitate the deletion of refractory HIV reservoirs.

Results

By singl

SUBMITTER: Li M 

PROVIDER: S-EPMC12302414 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature