Magnetic nanocatalyst for microwave-assisted synthesis of Benzo[4,5]imidazo[1,2-<i>a</i>]pyrimidines via A3 coupling.

ABSTRACT: This manuscript introduces an innovative and environmentally benign magnetic nanocatalyst (NiFe₂O₄@MCM-41@IL/Pt(II)) designed to synthesize benzoimidazo[1,2-a]pyrimidines via a microwave-assisted, one-pot A3 coupling reaction. The methodology employs aromatic and heteroaromatic aldehydes, 2-aminobenzimidazole derivatives, and terminal alkynes in water as a green solvent, leveraging the synergistic effects of nanocatalysis and microwave irradiation. The magnetic nanocatalyst, characterized by its robust structure and high surface reactivity, facilitates rapid reaction kinetics, achieving excellent yields while significantly reducing energy consumption and reaction time compared to conventional thermal approaches. Its inherent magnetic properties enable straightf

SUBMITTER: Pan Y 

PROVIDER: S-EPMC12302415 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature