Effect of mitochondrial translocator protein TSPO on LPS-induced cardiac dysfunction.

ABSTRACT:

Introduction

Sepsis-induced cardiac dysfunction is one of the most serious complications of sepsis. The mitochondrial translocator protein (TSPO), a mitochondrial outer membrane protein, is widely used as a diagnostic marker of inflammation-related diseases and can also lead to the release of inflammatory components. However, whether TSPO has a therapeutic effect on sepsis-induced cardiac dysfunction is unclear.

Objectives

The aim of this study is to investigate the involvement of TSPO in the pathogenesis of sepsis-induced cardiac dysfunction and elucidate its underlying mechanism, as well as develop therapeutic strategies targeting TSPO for the prevention and treatment of sepsis-induced cardiac dysfunction.

Methods

The sepsis-induced cardiac dysfunction model was est

SUBMITTER: Li X 

PROVIDER: S-EPMC12302418 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature