Co-expression of tissue factor, TROP2, and NECTIN4 in primary and matched metastatic cervical cancer lesions.

ABSTRACT:

Background

Early detection of cervical cancer (CC) generally leads to favorable prognosis; however, survival rates drop significantly for late-stage or recurrent disease with limited treatment options. Antibody-drug conjugates (ADCs) show promise across multiple cancers but remain sparsely explored in CC.

Objective

This study evaluates ADC target expression in primary and metastatic CC to identify potential ADC responders.

Study design

Membrane expression of tissue factor, TROP2 and NECTIN4 was investigated by immunohistochemistry in 522 primary and 194 metastatic CC lesions. Expression levels were scored according to the ASCO/CAP criteria and correlated with clinicopathological features and follow-up data.

Results

Tissue factor, TROP2, and NECTIN4 membranous e

SUBMITTER: Ulvang ML 

PROVIDER: S-EPMC12302420 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature