Neutrophil extracellular traps induced by Haemonchus contortus excretory-secretory proteins varies among goats, gerbils, and mice.

ABSTRACT:

Background

Previous studies indicated that infection with Haemonchus contortus is host-specific (goat: susceptible host; gerbil: paratenic host; mouse: resistant host). Neutrophils play an essential role in host defense against parasitic infection through phagocytic engulfment, reactive oxygen species (ROS) generation, and neutrophil extracellular traps (NETs) formation. NETs are large web-like complexes consisting of a DNA scaffold decorated with various proteins components, including histones, myeloperoxidase, and elastase. They are released through both ROS-dependent and ROS-independent pathways. Previous studies have demonstrated both constraints and effectiveness of NETs in helminths. However, the roles of NETs in anti-infection of H. contortus in different hosts are still unc

SUBMITTER: Tan Y 

PROVIDER: S-EPMC12302446 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature