Correlation between systemic inflammatory response syndrome and prognosis of patients with cirrhosis and hepatic encephalopathy.

ABSTRACT:

Background

Although systemic inflammatory response syndrome (SIRS) is associated with the progression of cirrhosis, its clinical significance in patients with cirrhosis and hepatic encephalopathy (HE) remains unclear.

Methods

Here, clinical data of 161 hospitalized patients with cirrhosis and HE were analyzed.

Results

Of these patients, 60 (37.3%) developed SIRS and 40 (24.8%) died during hospitalization. Risk factors for death during hospitalization on univariate Cox analysis were as follows: a model for end-stage liver disease (MELD) score > 18; SIRS; serum C-reactive protein (CRP) > 10 mg/L; white blood cells (WBC), neutrophils (NEU), neutrophils/lymphocyte ratios (NLR), serum total bilirubin (TBIL), alanine aminotransferase (ALT), aspartate aminotransferase (AST);

SUBMITTER: Zhang K 

PROVIDER: S-EPMC12302455 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature