Age-related macular degeneration, subretinal drusenoid deposits, and cuticular and calcified drusen in black and hispanic subjects.

ABSTRACT:

Background

Subretinal drusenoid deposits (SDDs), cuticular drusen, and calcified drusen have been linked to rapid progression of age-related macular degeneration (AMD). SDDs have also been linked to high-risk vascular diseases (HRVDs). However, SDDs, cuticular drusen, and calcified drusen have not been reported in Black and Hispanic populations. We report that these drusen phenotypes occur in Black and Hispanic AMD patients.

Methods

Twenty-three Black and Hispanic AMD subjects were identified in a published cross-sectional study of 200 AMD subjects. Spectral-domain optical coherence tomography, near-infrared reflectance imaging, and lipid profiles were obtained in the parent study. Masked readers assigned subjects into 2 groups: SDDs, present with or without drusen, and drus

SUBMITTER: Tan JM 

PROVIDER: S-EPMC12302460 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature