Imbalance between skeletal muscle and intermuscular fat predicts treatment failure in Crohn's disease: an imaging biomarker for risk stratification.

ABSTRACT:

Background

Sarcopenia is prevalent in Crohn's disease (CD) patients, but the prognostic value of skeletal muscle-to-intermuscular adipose tissue (IMAT) balance in penetrating CD remains unexplored.

Objective

To determine whether skeletal muscle-IMAT imbalance predicts non-surgical treatment failure in CD.

Methods

This retrospective study included CD patients undergoing computed tomography enterography (CTE, 2013-2022), stratified by disease behavior (penetrating vs. non-penetrating). Automated CTE segmentation algorithm quantified skeletal muscle and IMAT volumes at baseline. Skeletal muscle ratio was calculated as skeletal muscle/(skeletal muscle + IMAT). Sarcopenia was defined by the skeletal muscle area at the third lumbar vertebra. Patients received ≥1 year of non

SUBMITTER: Xiong Z 

PROVIDER: S-EPMC12302469 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature