Developing Patient-Derived 3D-Bioprinting models of pancreatic cancer.

ABSTRACT:

Introduction

Pancreatic cancer (PC) remains a challenging malignancy, and adjuvant chemotherapy is critical in improving patient survival post-surgery. However, the intrinsic heterogeneity of PC necessitates personalized treatment strategies, highlighting the need for reliable preclinical models.

Objectives

This study aimed to develop novel patient-derived preclinical PC models using three-dimensional bioprinting (3DP) technology.

Methods

Patient-derived PC models were established using 3DP technology. Genomic and histological analyses were performed to characterize these models and compare them with corresponding patient tissues. Chemotherapeutic drug sensitivity tests were conducted on the PC 3DP models, and correlations with clinical outcomes were analyzed.

Resu

SUBMITTER: Sun H 

PROVIDER: S-EPMC12302476 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature