Nanoscale Curvature Regulates YAP/TAZ Nuclear Localization Through Nuclear Deformation and Rupture.

ABSTRACT: Nuclear translocation of the transcription regulatory proteins yes-associated protein (YAP) and transcriptional coactivator with PDZ-binding motif (TAZ) is a critical readout of cellular mechanotransduction. Recent experiments have demonstrated that cells on substrates with well-defined nanotopographies demonstrate mechanoadaptation through a multitude of effects - increased integrin endocytosis as a function of nanopillar curvature, increased local actin assembly on nanopillars but decreased global cytoskeletal stiffness, and enhanced nuclear deformation. How do cells respond to local nanotopographical cues and integrate their responses across multiple length scales? This question is addressed using a biophysical model that incorporates plasma membrane (PM) curvature-dependent endocytosis

SUBMITTER: Francis EA 

PROVIDER: S-EPMC12302533 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature