Mesoporous Gold Nanospheres Confined Platinum Nanoclusters as Robust ROS and Oxygen Nanogenerators for NIR-II Hyperthermia Cancer Therapy.

ABSTRACT: While massive studies are focused on platinum (Pt)-based nanozyme for antitumor therapies, their therapeutic efficiency is deficient due to the weak catalytic activity in the highly complex tumor microenvironment. Herein, mesoporous gold nanospheres confined platinum nanoclusters (MGNSs@Pt) as robust hydroxyl radical and oxygen nanogenerators are achieved for multimodal therapies. Benefiting from the confinement effect of the mesopores in the MGNSs, the Pt nanoclusters (Pt NCs) demonstrate enhanced stability and catalytic activity, with a catalytic constant (K_cat) of 1.42 × 10⁶ s^-1, which is 2 and 5 orders magnitude higher than K_cat values of Pt-decorated non-porous gold nanoparticles and pure Pt NCs respectively. Density functional theory (DFT)

SUBMITTER: Cun F 

PROVIDER: S-EPMC12302635 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature