Immune Development in Early Life (IDEaL) longitudinal cohort study protocol: Identifying biomarkers of vaccine responsiveness, respiratory infection, and asthma.

ABSTRACT:

Background

Early-life immune development is a critical factor in predicting the risk of childhood respiratory infections, asthma, and poor vaccine responses. Identifying immune endotypes that predispose children to these conditions could lead to the development of predictive biomarkers and early interventions, potentially improving long-term health outcomes. The IDEaL (Immune Development in Early Life)-Rome prospective pediatric cohort, based at Children's Hospital Bambino Gesù (Rome, Italy), is part of a National Institutes of Health/National Institute of Allergy and Infectious Diseases-supported longitudinal observational study.

Objectives

To identify molecular biomarkers associated with increased susceptibility to respiratory infections, asthma, and poor vaccine responsiv

SUBMITTER: Amodio D 

PROVIDER: S-EPMC12302638 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature