Platelet Functional Profile Is Altered in Metabolic Dysfunction-Associated Steatotic Liver Disease.

ABSTRACT:

Background and aims

Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of chronic liver disease, often progressing to fibrosis and up to cirrhosis. Platelet activation plays a potential role in MASLD progression, but its functional profile across disease stages remains unclear. This study aimed to characterise the platelet functional profile and phenotype in patients with MASLD ≤ F2 and F3-F4 fibrosis compared to healthy controls.

Methods

We analysed biomarkers of in vivo platelet activation, including urinary 11-dehydro-thromboxane B2 (11-dh-TXB₂) and plasma soluble P-selectin. Platelet phenotype was assessed via microfluidic assays and flow cytometry, evaluating adhesion and fibrinogen receptor activation and Annexin V. Patients

SUBMITTER: Castelli M 

PROVIDER: S-EPMC12302667 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature