<i>Etv5</i> Is Required for Peripheral Nerve Function and the Injury Response.

ABSTRACT: The development of Schwann cells, which myelinate axons in the peripheral nervous system, is critically dependent on MEK/ERK signaling. While Ets-domain transcription factors (Etv1, Etv4, Etv5) are downstream effectors of this pathway, only Etv1 has been specifically linked to Schwann cell development. Here, we examined the functions of Etv5, which is expressed in Schwann cell precursors, neural crest cells and satellite glia, at embryonic stages and at low levels in mature Schwann cells. In hypomorphic Etv5^tm1Kmm homozygous mutant mice, no overt defects in Schwann cell differentiation were observed at embryonic stages. To study the function of Etv5 in juvenile (postnatal days 21-30) and mature adult (6 month) mice, we generated <

SUBMITTER: Belfiore L 

PROVIDER: S-EPMC12302669 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature