Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids.

ABSTRACT:

Background

Cartilage repair remains a considerable challenge in regenerative medicine. Despite extensive research on biomaterials for cartilage repair in recent years, issues such as prolonged repair cycles and suboptimal outcomes persist. Organoids, miniature three-dimensional (3D) tissue structures derived from the directed differentiation of stem or progenitor cells, mimic the structure and function of natural organs. Therefore, the construction of cartilage organoids (COs) holds great promise as a novel strategy for cartilage repair.

Methods

This study employed a digital light processing system to perform 3D bioprinting of a DNA-silk fibroin (DNA-SF) hydrogel sustained-release system (DSRGT) with bone-marrow mesenchymal stem cells (BMSCs) to construct millimeter-scale ce

SUBMITTER: Shen CY 

PROVIDER: S-EPMC12302690 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature