Pharmacological upregulation of macrophage-derived itaconic acid by pubescenoside C attenuated myocardial ischemia-reperfusion injury.

ABSTRACT:

Introduction

Myocardial ischemia-reperfusion injury (MIRI) remains a prevalent clinical challenge globally, lacking an ideal therapeutic strategy. Macrophages play a pivotal role in MIRI pathophysiology, exhibiting dynamic inflammatory and resolutive functions. Macrophage polarization and metabolism are intricately linked to MIRI, presenting potential therapeutic targets. Pubescenoside C (PBC) from Ilex pubescens showed significantly anti-inflammatory effects, however, the effect of PBC on MIRI is unknown.

Objectives

This study aimed to assess the cardioprotective effects of PBC against MIRI and elucidate the underlying mechanisms.

Methods

Sprague-Dawley rats, H9c2 and RAW264.7 macrophages were used to establish the in vitro and in vivo models of MIRI. TTC/Evans blue

SUBMITTER: Chen S 

PROVIDER: S-EPMC12302717 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature