Implications of lipoprotein (a) [Lp(a)] gene polymorphic sequence variations and its protein expression in venous thromboembolism (VTE).

ABSTRACT:

Background

Venous thromboembolism (VTE) is a significant global health concern, with an annual incidence of approximately 1-2 per 1000 individuals. VTE is a major cause of morbidity and mortality worldwide, leading to substantial healthcare costs due to hospitalizations, long-term anticoagulation therapy, recurrent thrombotic events and the need for lifelong clinical management. The burden of VTE is particularly pronounced in aging populations, with incidence rates increasing exponentially after the age of 50. Despite its significant impact, the genetic underpinnings of VTE remain incompletely understood. This study investigates the association of Lp(a) gene polymorphisms (93C > T and 121G > A) and Lp(a) expression with VTE risk.

Methods

A case-control study was conducted, e

SUBMITTER: Happa K 

PROVIDER: S-EPMC12302730 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature