A combined measure of blood leukocytes, forced vital capacity and quantitative CT is highly predictive of mortality in IPF: results of a single-centre cohort study.

ABSTRACT:

Background

Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic condition. Serial FVC monitoring is most commonly used to assess progression of disease but FVC does not always reflect regional CT change in IPF. Recently there has been growing interest in quantitative CT (qCT) assessment of IPF. In this study, we compared different physiological and qCT measurements of disease progression in predicting mortality in IPF.

Aims

We question if a composite measure of disease progression using qCT and FVC is more predictive of mortality than individual measurements, and if addition of blood leukocyte levels further enhance predictive ability of these measurements of disease progression.

Methods

We conducted a retrospective analysis of an IPF cohort (n = 71). Annuali

SUBMITTER: Achaiah A 

PROVIDER: S-EPMC12302753 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature