<i>In vivo</i> human neurite exchange time imaging at 500 mT/m diffusion gradients: Neurite exchange time imaging on Connectome 2.0.

ABSTRACT: Evaluating tissue microstructure and membrane integrity in the living human brain through diffusion-water exchange imaging is challenging due to requirements for a high signal-to-noise ratio and short diffusion times dictated by relatively fast exchange processes. The goal of this work was to demonstrate the feasibility of in vivo imaging of tissue micro-geometries and water exchange within the brain gray matter using the state-of-the-art Connectome 2.0 scanner equipped with an ultra-high-performance gradient system (maximum gradient strength=500 mT/m, maximum slew rate=600 T/m/s). We performed diffusion MRI measurements in 15 healthy volunteers at multiple diffusion times (13-30 ms) and b-values up to 17.5 ms/μm². The anisotropic Kärger model was applied to estima

SUBMITTER: Chan KS 

PROVIDER: S-EPMC12302768 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature