Plumbagin targets the GLUT1/MMP-2 axis to inhibit oral squamous cell carcinoma progression.

ABSTRACT:

Aim

This study aimed to investigate the clinicopathological characteristics and prognostic value of GLUT1 in oral squamous cell carcinoma (OSCC) and the effect of plumbagin (PLB) on inhibiting OSCC invasion and metastasis through the GLUT1/Matrix Metalloproteinase 2 (MMP2) axis pathway.

Materials and methods

One hundred and twenty human OSCC specimens were collected. Immunohistochemistry was performed to analyze the expression, clinicopathological characteristics, and prognostic value of GLUT1 in these specimens. Cal27 and SCC9 cell lines were used to investigate the role of PLB in cell proliferation, migration, invasion, and metastasis in vitro and in vivo.

Results

Immunohistochemistry showed significant associations between GLUT1 expression and MMP2, tumor recurrenc

SUBMITTER: He F 

PROVIDER: S-EPMC12302832 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature