Combating biofilm formation and bacterial killing: N-acetylcysteine's efficacy against <i>Pseudomonas aeruginosa</i> in urinary catheters.

ABSTRACT: Uropathogenic Pseudomonas aeruginosa is a significant contributor to catheter-associated urinary tract infections (CA-UTIs), distinguished by its unique biofilm-forming properties compared to other strains. Despite its clinical significance, optimized strategies for biofilm eradication in the bladder and on catheters remain limited. Thus, the aim of this study was to highlight the potent antibacterial and biofilm-inhibitory effects of N-acetyl cysteine (NAC) against uropathogenic P. aeruginosa. Additionally, we sought to investigate its effect against catheter obstruction caused by P. aeruginosa in a patient, and whether this phenomenon can be replicated in vitro to underscore the urgency of addressing this critical challenge. We demonstrated that uropathogenic

SUBMITTER: Manoharan A 

PROVIDER: S-EPMC12302843 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature