Pilaralisib inhibits the replication of enteroviruses by targeting the PI3K/AKT signaling pathway.

ABSTRACT: Enterovirus 71 (EV71) is a significant pathogen responsible for hand, foot, and mouth disease (HFMD), which poses a substantial public health concern, particularly in the Asia-Pacific region. The virus is transmitted primarily through the fecal-oral route and via respiratory droplets, entering the host via the gastrointestinal tract where it replicates before spreading to the central nervous system. The virus predominantly affects children under five years of age, often resulting in severe neurological complications, including aseptic meningitis, acute flaccid paralysis, and, in some cases, death. Despite the development of vaccines, global control of EV71 remains challenging due to its high genetic variability. The PI3K/Akt signaling pathway plays a critical role in regulating various cel

SUBMITTER: Zhou J 

PROVIDER: S-EPMC12302845 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature