Oral and gut microbiota in gingivitis subtypes: a causal inference study using Mendelian randomization.

ABSTRACT:

Background

The disruption of microbiota balance could be a pivotal factor in the complications arising from periodontal disease-induced inflammation outside the mouth. Nonetheless, it remains uncertain whether there is a direct causal relationship between the oral and gut microbiomes and gingivitis, especially in distinguishing between acute and chronic gingivitis.

Methods

We performed a two-sample Mendelian randomization (MR) analysis using GWAS summary statistics from FinnGen data (149 acute gingivitis cases, 850 chronic gingivitis cases, and 195,395 controls) to explore the causal role of oral and gut microbiota. The primary analysis employed the inverse-variance weighted (IVW) method, augmented by four supplementary approaches: weighted median, weighted mode, and MR Egge

SUBMITTER: Lin J 

PROVIDER: S-EPMC12302868 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature