Universal orthologs infer deep phylogenies and improve genome quality assessments.

ABSTRACT:

Background

Universal single-copy orthologs are the most conserved components of genomes. Although they are routinely used for studying evolutionary histories and assessing new assemblies, current methods do not incorporate information from available genomic data.

Results

Here, we first determine the influence of evolutionary history on universal gene content and find that across 11,098 genomes of plants, fungi, and animals comprising 2606 taxonomic groups, 215 groups significantly vary from their respective lineages in terms of BUSCO (Benchmarking Universal Single Copy Orthologs) completeness. Additionally, 169 groups display an elevated complement of duplicated orthologs, likely from ancestral whole genome duplication events. Secondly, we investigate the extent of taxonomic

SUBMITTER: Alam MNU 

PROVIDER: S-EPMC12302877 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature