Dynamic association of serum albumin changes with inflammation, nutritional status and clinical outcomes: a secondary analysis of a large prospective observational cohort study.

ABSTRACT:

Background

Serum albumin (ALB) has traditionally been regarded as a marker of nutritional status. However, recent studies suggest its changes are closely linked to inflammation, metabolic dysregulation, and disease severity, limiting its role as a sole indicator of nutritional status. Yet, clinical practice continues to rely on ALB to monitor nutritional interventions, with a paucity of high-quality evidence on its dynamic associations with clinical outcomes. This study aimed to investigate the comprehensive associations of ALB dynamics with inflammation, nutritional status, and clinical outcomes in hospitalized patients, providing evidence to optimize clinical management.

Methods

This secondary analysis utilized data from a prospective observational cohort study conducted i

SUBMITTER: Li Y 

PROVIDER: S-EPMC12302892 | biostudies-literature | 2025 Jul

REPOSITORIES: biostudies-literature