Grey Matter Volume in Substance Use: A Preregistered, Dimensional Approach to Disentangle Substance Use and Disorder Severity.

ABSTRACT: This preregistered study investigates whether altered grey matter volume (GMV) in the insula and ventromedial prefrontal/anterior cingulate cortex (vmPFC/ACC) - regions commonly implicated in substance use disorder (SUD) - is associated with the degree of substance use or with the severity of substance-related problems, two distinct but correlated facets of SUD. Baseline structural MRI and behavioural assessment of substance use, substance-related problems (i.e., DSM-5 disorder severity) and negative urgency were conducted in 134 (poly-)substance users. At 1-year follow-up, behavioral assessments were repeated in 120 participants. Linear regression analyses tested associations between GMV in predefined regions (insula, vmPFC and ACC) and (1) degree of use, (2) substance-related problems an

SUBMITTER: Schwarz K 

PROVIDER: S-EPMC12302895 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature