Association of prognostic nutritional index with all-cause mortality and cardiovascular mortality: a nationwide population-based cohort study.

ABSTRACT:

Background

The prognostic nutritional index (PNI) has shown prognostic value in various diseases, but its association with mortality in the general population remains unclear.

Methods

We analyzed data from 30,741 adults in the National Health and Nutrition Examination Survey (NHANES) 2007-2018. Cox proportional hazard models examined the association between PNI and mortality outcomes. Restricted cubic spline analyses were performed to assess non-linear relationships. Subgroup analyses were conducted to evaluate effect modifications.

Results

During follow-up, higher PNI values were associated with lower all-cause mortality (HR: 0.95, 95% CI: 0.94-0.96) and cardiovascular mortality (HR: 0.94, 95% CI: 0.93-0.96). Non-linear relationships were identified with threshold ef

SUBMITTER: Zhou C 

PROVIDER: S-EPMC12302918 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature