Prenatal Stress and Socioeconomic Status as Predictors of Placental Methylation in Pregnant People.

ABSTRACT: Despite growing interest in placental epigenetics, the combined impact of prenatal stress and socioeconomic status (SES) on placental methylation is still largely understudied. We conducted a study to examine the associations of prenatal stress and socioeconomic factors (household income, Hollingshead socioeconomic index) with placental methylation. Pregnant people (n = 143; M _age = 25.66) in their second or third trimester (M _{gestational age} = 23.11 weeks) completed self-report questionnaires including demographic and socioeconomic information and ratings of perceived stress in the past month. Placenta tissue samples were collected after birth, from which placental genomic DNA was extracted to assess methylation levels at the NR3C1

SUBMITTER: Santander CJ 

PROVIDER: S-EPMC12302960 | biostudies-literature | 2024 Jul

REPOSITORIES: biostudies-literature