Effects of Esketamine Combined With Remimazolam Tosylate on Hemodynamics During Cardiovascular Anesthesia.

ABSTRACT: This study aimed to evaluate the effects of esketamine combined with remimazolam tosylate on hemodynamic stability, cerebral oxygen metabolism, and cognitive outcomes in patients undergoing heart valve replacement. Seventy-eight patients were randomized to Group C (dexmedetomidine hydrochloride) or Group R (esketamine + remimazolam tosylate). The following parameters were measured: multiple time points, including mean arterial pressure (MAP), heart rate (HR), respiratory rate (RR), arterial-jugular vein oxygen content difference (Da-jvO₂), cerebral oxygen uptake rate (CERO₂), and biomarkers of myocardial injury (cTnI, CK-MB, FABP) at baseline (T0), incision (T1), sternotomy (T2), pre-cardiopulmonary bypass (T3), and post-surgery (T4). Cognitive function was assessed u

SUBMITTER: Xi L 

PROVIDER: S-EPMC12302974 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature