P75^NTR activation limits CD21^lo B cell subsets expansion in response to autoimmune-inducing challenges.

ABSTRACT: Studies, including our own, suggest that p75^NTR plays a pivotal role in immune regulation. Here, we aimed to uncover the role of p75^NTR signaling in regulating CD21^lo B cell subsets, which are known to facilitate autoimmune activity, and to identify possible regulatory transcripts involved. Through in vitro assays, in vivo models, and RNA-seq analysis, we found that p75^NTR expression and CD21^lo B cell expansion were increased in B cells following TLR7/9 stimulation in vitro and in pristane-challenged mice in vivo. Interestingly, p75^NTR deficiency led to a further expansion of CD21^lo B cells and enhanced their pro-inflammatory characteristics. RNA-seq data revealed notable transcript alt

SUBMITTER: Luo C 

PROVIDER: S-EPMC12303049 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature