Predictors of response to peri-arrest bolus epinephrine in children.

ABSTRACT:

Aim

To explore clinical characteristics associated with hemodynamic response to initial dosing of peri-arrest bolus epinephrine (PBE) for acute hypotension in the PICU.

Methods

Single center retrospective cohort study of patients < 19 years old who received PBE for acute hypotension in the pediatric intensive care units at our institution from April 2017 to September 2023. Change in systolic blood pressure (SBP) was measured within 5 min before and after PBE. Patients were categorized as non-responders if the change in SBP was ≤ 10 mmHg. The primary analysis used a multivariate logistic regression model to determine factors associated with responder status via manual backward stepwise regression. Post-hoc analyses using Pearson correlation assessed the relationship of age, P

SUBMITTER: Sorcher JL 

PROVIDER: S-EPMC12303060 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature