Predicting cellular adaptation proteins dependent on eIF2α regulation under stress conditions: Physiological and pathophysiological implications in neuronal function.

ABSTRACT: Understanding the intricate mechanisms governing gene expression regulation is crucial for deciphering neuronal responses to cellular stress at both the physiological (i.e., synaptogenesis) and pathophysiological (i.e., neurodegenerative diseases) levels. These rapid adaptive changes depend on the translation of specific proteins with specialized 5' untranslated regions (5'UTRs), triggered by the phosphorylation of eukaryotic initiation factor 2 alpha (eIF2α), while normal cellular translation remains largely inhibited. This study aims to provide a useful tool to identify mRNAs susceptible to regulation by p-eIF2α. We compiled a database of 5'UTRs using Ensembl canonical transcripts from the GRCh38.p14 genome build. Ensembl IDs were used to extract coding sequences and cDNA via the REST AP

SUBMITTER: Herrera-Fernandez V 

PROVIDER: S-EPMC12303066 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature