3D <i>in vitro</i> modeling of neural microenvironment through a multi-scaffold assembly approach.

ABSTRACT: The engineering of in vitro 3D cell culture systems has emerged as promising approach to model central nervous system (CNS) intricacy with increasing physiological relevance. The fabrication of artificial microenvironments that closely resemble nervous tissue composition and architecture has provided useful substrates to promote neural cell growth and maturation under in vivo-like conditions; however, despite significant progress has been made in tissue mimicry, directing neural cell arrangement and connectivity in a controlled 3D environment remains extremely challenging. Here, we propose a novel approach that combines different biomaterials and biofabrication techniques to develop a multi-scaffold system mimicking distinctive features of the nervous tissue. Extrusion-based

SUBMITTER: Traldi C 

PROVIDER: S-EPMC12303067 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature