Diagnostic value of long noncoding RNAs as biomarkers for Ankylosing Spondylitis: A systematic review and meta-analysis.

ABSTRACT:

Introduction

Ankylosing spondylitis (AS) presents as a debilitating form of arthritis with potential for severe damage. In chronic cases, patients may experience progression to ankylosis and spinal immobility, significantly diminishing their quality of life. Given these challenges, there is a pressing need to explore novel diagnostic targets. Thus, this study aimed to evaluate the diagnostic potential of long non-coding RNAs (lncRNAs) for AS.

Methods

The search encompassed various databases including PubMed, Scopus, Embase, and Hinari. Analysis of pooled sensitivity, specificity, positive likelihood ratio (PLR), negative likelihood ratio (NLR), diagnostic odds ratio (DOR), and area under the curve (AUC) was carried out using Stata 17.0 software, employing a random effects mo

SUBMITTER: Alemayehu E 

PROVIDER: S-EPMC12303277 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature