Mathematical bridge between epidemiological and molecular data on cancer and beyond.

ABSTRACT:

Background

Background: At least six different mathematical models of cancer and their countless variations and combinations have been published to date in the scientific literature that reasonably explain epidemiological prediction of multi-step carcinogenesis. Each one deals with a particular set of problems at a given organizational level ranging from populations to genes. Any of the models adopted in those articles so far do not account for both epidemiological and molecular levels of carcinogenesis.

Methods

We have developed a mathematically rigorous system to derive those equations satisfying the basic assumptions of both epidemiology and molecular biology without incorporating arbitrary numerical coefficients or constants devoid of any causal explanation just to fit th

SUBMITTER: Chakravarty S 

PROVIDER: S-EPMC12303294 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature