Phosphatidylcholine suppresses inflammatory responses in LPS-stimulated MG6 microglial cells by inhibiting NF-κB/JNK/p38 MAPK signaling.

ABSTRACT: Phosphatidylcholine (PC), a choline-containing phospholipid abundant in chicken eggs, is widely consumed as a dietary supplement. Epidemiological studies suggest that PC intake may improve cognitive function in patients with neurodegenerative diseases such as Alzheimer's disease, although the underlying mechanisms remain largely unclear. In this study, we investigated the anti-inflammatory effects of PC and its molecular mechanisms using an in vitro inflammation model involving lipopolysaccharide (LPS)-stimulated MG6 mouse microglial cells. PC significantly suppressed the LPS-induced expression of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6). Mechanistically, PC inhibited the phosphorylation of inhibitor kappa Bα (I

SUBMITTER: Mizuno S 

PROVIDER: S-EPMC12303320 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature