Effects of standard and low doses of estradiol on markers of endometrial receptivity in frozen-thawed embryo transfer cycles: Double-blind, randomized clinical trial.

ABSTRACT:

Background

Endometrial receptivity biomarkers, specifically the regulatory proteins HOXA-10 and HOXA-11 as well as the integrin αvβ3, play vital roles in implantation during the window of implantation. This Double-blinded, randomized clinical trial compares the effects of two initial doses of oral estrogen regimens on endometrial receptivity markers during the window of implantation in endometrial preparation for frozen-thawed embryo transfer.

Methods and findings

The study includes infertile patients who underwent in vitro fertilization and planned frozen-thawed embryo transfer at the infertility clinic between June 2018 and March 2019. Fifty patients were randomized to a low-dose (4 mg/day) or standard-dose (6 mg/day) estradiol group for artificial endometrial preparation.

SUBMITTER: Parkpinyo N 

PROVIDER: S-EPMC12303338 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature